Ard van Sighem
Ard's research involves investigating the course and the changes in the HIV epidemic in the Netherlands from the early 1980s until the present day. To achieve this, Ard uses mathematical modelling as a tool to analyse the relevant data in the ATHENA cohort, the database maintained by Stichting HIV Monitoring, and other national data sources. Ard is investigating how HIV spreads within risk groups, how these risk groups have changed over time, and how interventions would act on the future course of the epidemic.
He is also interested in the more patient-specific side of the HIV epidemic. In particular, Ard is investigating the risk of progression to death in the era of combination treatment in which specific groups of patients can achieve a near normal life expectancy. In addition, he is studying incidence of and risk factors for non-AIDS diseases in the ageing HIV-infected population, in particular their relation with CD4 cell counts and HIV RNA levels.
Lastly, together with the European Centre for Disease Control and Prevention and with colleagues in the United Kingdom and Switzerland, Ard is investigating and improving methods to estimate the size of HIV population in countries within the European Union and the European Economic Area.
Ard was trained as a particle physicist at Leiden University and obtained his PhD in 2000 at the University of Amsterdam. Subsequently, Ard became a researcher with the AIDS Therapy and Evaluation Netherlands (ATHENA) project which investigated the long-term efficacy, safety, and outcome of the at that time new combination antiretroviral treatment. Since 2002,he has worked as a senior researcher for Stichting HIV Monitoring.
Sources of HIV infection among men having sex with men and implications for prevention
Ratmann O, van Sighem A, Bezemer D, Gavryushkina A, Jurriaans S, Wensing A, de Wolf F, Reiss P, Fraser C
ATHENA observational cohort.
Sci Transl Med. 2016 Jan 6;8(320):320ra2. doi: 10.1126/scitranslmed.aad1863
A Method to Estimate the Size and Characteristics of HIV-positive Populations Using an Individual-based Stochastic Simulation Model
Nakagawa F, van Sighem A, Thiebaut R, Smith C, Ratmann O, Cambiano V, Albert J, Amato-Gauci A, Bezemer D, Campbell C, Commenges D, Donoghoe M, Ford D, Kouyos R, Lodwick R, Lundgren J, Pantazis N, Pharris A, Quinten C, Thorne C, Touloumi G, Delpech V, Phillips A
SSOPHIE project working group in EuroCoord. Epidemiology. 2016 Mar;27(2):247-56
Dispersion of the HIV-1 Epidemic in Men Who Have Sex with Men in the Netherlands: A Combined Mathematical Model and Phylogenetic Analysis
Bezemer D, Cori A, Ratmann O, van Sighem A, Hermanides HS, Dutilh BE, Gras L, Rodrigues Faria N, van den Hengel R, Duits AJ, Reiss P, de Wolf F, Fraser C
ATHENA observational cohort. PLoS Med. 2015 Nov 3;12(11):e1001898.
Comparative effectiveness of immediate antiretroviral therapy versus CD4-based initiation in HIV-positive individuals in high-income countries: observational cohort study
Lodi S, Phillips A, Logan R, Olson A, Costagliola D, Abgrall S, van Sighem A, Reiss P, Miró JM, Ferrer E, Justice A, Gandhi N, Bucher HC, Furrer H, Moreno S, Monge S, Touloumi G, Pantazis N, Sterne J, Young JG, Meyer L, Seng R, Dabis F, Vandehende MA, Pérez-Hoyos S, Jarrín I, Jose S, Sabin C, Hernán MA
HIV-CAUSAL Collaboration. Lancet HIV. 2015 Aug;2(8):e335-43
Estimating HIV Incidence, Time to Diagnosis, and the Undiagnosed HIV Epidemic Using Routine Surveillance Data
van Sighem A, Nakagawa F, De Angelis D, Quinten C, Bezemer D, de Coul EO, Egger M, de Wolf F, Fraser C, Phillips A.
Epidemiology. 2015 Sep;26(5):653-60
Life expectancy of recently diagnosed asymptomatic HIV-infected patients approaches that of uninfected individuals
van Sighem AI, Gras LA, Reiss P, Brinkman K, de Wolf F
ATHENA national observational cohort study. AIDS. 2010 Jun 19;24(10):1527-35