Imperial College London & BEEHIVE
SHM has had a longstanding collaboration since 2002 with the Department of Infectious Disease Epidemiology (DIDE), which is part of the Faculty of Medicine, Imperial College London. The collaboration focuses on using mathematical modelling and viral phylogenetics to improve our understanding of the HIV epidemic and the potential impact of different interventions, including ‘treatment as prevention’ and pre-exposure prophylaxis (PrEP). Until recently, Prof. Christophe Fraser coordinated the collaboration with SHM as part of the faculty at Imperial College London, and currently continues to do so from his new position at the Big Data Institute of Oxford University’s Li Ka Shing Centre for Health Information and Discovery.
In the Bridging the Epidemiology and Evolution of HIV in Europe (BEEHIVE) project (ERC grant to Prof. Fraser), Oxford University, Imperial College’s DIDE, and SHM collaborate with the AMC-UvA and the Sanger Institute, UK, on a viral whole genome association study. The primary aim of this study is to identify viral virulence factors, which could ultimately shed new light on the pathogenesis of HIV.
SHM also closely collaborates with Imperial College’s DIDE (Dr Mikaela Smit and Prof. Tim Hallett) in modelling the future burden of non-communicable comorbidity and the expected impact of various interventions in the ageing population with HIV in care in the Netherlands.
Key publications in 2017:
Viral genetic variation accounts for a third of variability in HIV-1 set-point viral load in Europe
Blanquart F, Wymant C, Cornelissen M, Gall A, Bakker M, Bezemer D, Hall M, Hillebregt M, Ong SH, Albert J, Bannert N, Fellay J, Fransen K, Gourlay AJ, Grabowski MK, Gunsenheimer-Bartmeyer B, Günthard HF, Kivelä P, Kouyos R, Laeyendecker O, Liitsola K, Meyer L, Porter K, Ristola M, van Sighem A, Vanham G, Berkhout B, Kellam P, Reiss P, Fraser C; BEEHIVE collaboration.
PLoS Biol. 2017 Jun 12;15(6):e2001855. doi: 10.1371/journal.pbio.2001855. eCollection 2017 Jun
Cardiovascular disease prevention policy in human immunodeficiency virus: recommendations from a modeling study
Smit M, van Zoest RA, Nichols BE, Vaartjes I, Smit C, van der Valk M, van Sighem A, Wit FW, Hallett TB, and Reiss P; for The Netherlands’ AIDS Therapy Evaluation in The Netherlands (ATHENA) Observational HIV Cohort
Clinical Infectious Diseases, cix858, https://doi.org/10.1093/cid/cix858