Harmonic is a collaboration launched in 2014 between two HIV/hepatitis treatment centres in the Netherlands, UMC Utrecht and Rijnstate in Arnhem, and SHM, to compare patients with a hepatitis B (HBV) mono-infection with those with HIV/HBV co-infection. This retrospective study aims to compare the natural course of HBV, the morbidity and mortality associated with the infection, and the effect of treatment between mono-infected and HIV co-infected patients. SHM contributes to Harmonic by making data available on HIV/HBV co-infected individuals registered in SHM’s database, and by implementing the data collection of HBV mono-infection at both study sites. Furthermore, SHM provides database management, data sets for analysis, and contributes analytic and scientific support and supervision.

Recent Harmonic publications:

Liver decompensation in HIV/hepatitis B coinfection in the cART era does not seem increased compared to hepatitis B mono-infection
Lieveld FI, Smit C, Richter C, van Erpecum KJ, Spanier BWM, Gisolf EH, Vrolijk JM, Siersema PD, Hoepelman AIM, Reiss P, Arends JE.
Liver Int. 2018 Nov 9. doi: 10.1111/liv.14000. [Epub ahead of print]