Logo_CASCADE.pngConcerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) was established in 1997 as a collaboration between 25 cohorts of documented HIV seroconverters from 15 European countries, Australia, Canada and Africa. CASCADE’s main aim is to monitor the course of HIV infection from the time of infection onwards. By pooling data, issues can be addressed that cannot be reliably addressed from single studies alone. The Amsterdam Cohort Studies (ACS) participates in this study.

CASCADE was part of EuroCoord, the collaboration that encompassed all EU-funded cohort studies in the field of HIV and that ended in 2015. For the time being, scientific productivity within CASCADE is continuing based on the last available joint dataset.

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In 2017, the following publications were published by CASCADE:

Lack of decline in hepatitis C virus incidence among HIV-positive men who have sex with men during 1990-2014
van Santen DK, van der Helm JJ, Del Amo J, Meyer L, D'Arminio Monforte A, Price M, Béguelin CA, Zangerle R, Sannes M, Porter K, Geskus RB, Prins M; CASCADE Collaboration in EuroCoord.
J Hepatol. 2017 Aug;67(2):255-262. doi: 10.1016/j.jhep.2017.03.038. [Epub 2017 Apr 12]

Predictors of CD4 cell recovery following initiation of antiretroviral therapy among HIV-1 positive patients with well-estimated dates of seroconversion
Stirrup OT, Copas AJ, Phillips AN, Gill MJ, Geskus RB, Touloumi G, Young J, Bucher HC, Babiker AG; CASCADE Collaboration in EuroCoord.
HIV Med. 2017 Dec 1. doi: 10.1111/hiv.12567. [Epub ahead of print]